Oyster 406 - large owners cabin in the stern, smaller double cabin in the bow, 2 ensuite heads, good headroom and reasonable saloon and linear galley. Admittedly though the cockpit is a bit small.
Many things are simpler with the wheel-going astern you can still stand behind the wheel -there is space for instruments going forward,the autopilot is simple to use . It gives a fixing point for the cockpit table and any other stuff needed , provides a bracing point in cockpit. If you must can attach mainsheet to it so it’s handy etc. I am sure many sail larger craft with tiller but the wheel as said gives simplicity to newish sailors -just watch how they teach newbies to back into a mooring on Greek charter fleets -maybe a weeks charter with the friends on a smaller yacht with single wheel might help?