We did a circuit last summer from St Jean de Losne, up the Rhone-Rhine canal to Mulhouse, then down the Rhine to Koblenz, back up the Mosel to Nancy, and through the Vosges back to the Saone. We kept a blog for friends and family, which you can see here: http://nwrparsons.blogspot.fr/
It was a trip that I would thoroughly recommend: the Rhine was very exciting, particularly the Lorelei Gorge! However, I would counsel against going upstream, unless you have a very powerful engine and deep pockets for fuel: the current was extremely strong.
