Depends where you are going to sail but assuming for general free ranging cruising use rather than just local marina hopping I would agree with AndrewB's "at least 75lb".
Our main anchor on a much smaller 40 foot yacht is a 60lb CQR type on 10mm chain and we have been a number of times thankful for the big (relatively speaking) anchor.
Some will say that weight is essentially irrelevant because it is the presented area of the anchor that provides the holding, however, in my view weight (up to a limit) is a big factor in setting and ability to reliably reset and that is important for a self sufficient vessel. I say that realising some boats cannot carry the weight (eg cats) in which case one must compromise.
there are newer designs which are more effective for a given weight than the CQR. It is also prone to joint wear after long use resulting in lower holding power. also beware of cheaper imitations which look just the same but are much less effective.
consider a delta as a bower and a big fortress for emergencies and soft mud.
The wt of the boat has little relevence to ground takle since it only affects snatching load, it is the windage (and water drag in a tideway) that counts. I looked after a 55ft motor boat which although it has more superstructure has no mast or keel so probably similar. Used 45lb CQR's as kedge/lunch hook and a 250lb ship pattern bower which seamed ok. For seriouse cruising I would expect to find twin bowers of at least 120lb capable of being deployed in tandom plus backups and 2 kedges. Agree chain should be at least 14mm. Given that ground takle on a boat this size is inevitably to big to manhandle you might as well get the biggest you can carry. Bear in mind also you are much more likely to be in an exposed anchorage because of size and draft and just because you can confortably ride a bigger swell.
"The wt of the boat has little relevence to ground takle " I agree with you until the boat is anchored in protected waters.. B U T..
If there is some swell or waves entering the mooring and if the boat is moving forth and back.. then in addition to the force exerted by the wind, there is a cynetic energy = to 1/2 M*V² where V is the displacement speed of the boat and M is the Weight of the boat..
Therefor you have to select your anchor, not only in relation to the surface exposed to the wind but ALSO to the displacement of the boat..
You will find more precise explanation on: http:alain.fraysse.free.fr
The principle is right but the reason for saying wt is no the significant factor UNLESS SNUBBING is that the wt of chain/elasticity of rope should absorb this energy not transmit it to the anchor. If it dosn't the anchor will snub and the shock load break almost anything out so the answer would be more scope or a heavier chain not a heavier anchor. Personally I think this is a big factor in dragging, my own boat (32ft long keel) carries 2 45lb bower that can be linked to give 90lb but the 110m of 10mm chain is still several time heavier. In practice I work on the principle of carrying the heaviest gear practical and using 8 or 10 to 1 scope in a blow.